Next Sleep is a formulary blend of botanicals, nutrients, neurotransmitters, and neurotransmitter precursors designed to support quality sleep and the promotion of calming brain activity. Next Sleep promotes GABAnergic and seritonergic activity, supporting the ability to get to sleep, and stay asleep. Now clinicians can attain all of the various interventions typically used in natural promotion of quality sleep in one product, improving patient convenience and compliance.
Key Ingredients of Next Sleep
Next Sleep contains valerian root (Valeriana officinalis), passion flower (Passiflora incarnata), and lemon balm (Melissa officinalis), all safe nervine botanicals known for their relaxant properties and ability to reduce tension and promote sleep, without causing morning grogginess.
Valerian root has demonstrated sedative effects due to its ability to induce the release of GABA from brain tissue. It has been suggested that the passion flower and German chamomile (Matricaria recubita) constituent apigenin binds to central ben-zodiazepine receptors, possibly causing anxiolytic effects (anxiety reducing) without impairing memory, diminishing mo- tor skills, or causing drowsiness upon awakening. Lemon balm has been suggested to improve calmness via the inhibitory action of GABA, similar to benzodiazepine, but without the overt side-effects of these medications. Direct stimulation of Gamma aminobutyric acid (GABA), the main calming neurotransmitter in the body, is provided with a new form of GABA known as PharmaGABATM, a proprietary material naturally manufactured via a fermentation process and considered more effective than other traditional, chemically produced synthetic forms. In addition, support of calming neurotransmitter pro- duction is provided with the inclusion of L-theanine, clinically proven to reduce stress and improve the quality of sleep.
Next Sleep also includes melatonin, a multifunctional hormone whose main role lies in its involvement in the control of the circadian (day/night) biological rhythms. Melatonin mediates the body's response to variations of natural light availabil- ity from indoor/outdoor exposure or due to seasons (winter/summer). Darkness into the eye tells the brain to make melatonin so the body can prepare for sleep mode. Its production should peak at night and it is instrumental for maintaining quality sleep patterns. Melatonin production declines significantly with age, often causing sleep difficulties associated with aging. Supplemental melatonin was shown in studies to help with falling asleep when taken about 30 minutes before the desired sleep time. The most common dose found effective for sleep was 3mg.
5-HTP can be used in conjunction with melatonin, as a precursor to serotonin, which can further support endogenous mela- tonin production during the night to help with staying asleep. When using 5-HTP for enhancing serotonin and melatonin production to promote healthy mood and sleep, the addition of the synergistic nutrient pyridoxal-5-phosphate, an activated form of vitamin B6, is suggested to catalyze the conversion of 5-HTP to serotonin (5-HT).