Next Buffered C

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10.6 fl. oz
Potent antioxidant protection, as it helps combat cellular damage from free radicals caused by oxidative stress.
$39.99
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Vitamin C is a water-soluble vitamin most widely known for its role in supporting immune health. It provides potent antioxidant protection, as it helps combat cellular damage from free radicals caused by oxidative stress, thus protecting health overall. Vitamin C also boosts the function of immune cells and is a key nutrient in the synthesis of collagen. Buffered C Powder is balanced with calcium, magnesium and potassium to gently deliver high-concentration vitamin C to reduce the potential of gastrointestinal upset.

Overview
Vitamin C’s role in immune enhancement has been strongly evidenced in supplementation research to increase natural killer cell activity, lymphocyte proliferation and immune balance.[1] Vitamin C is also a potent antioxidant, acting to neutralize free radical damage to cells, including DNA, lipids and proteins. As a free radical neutralizing agent, vitamin C readily donates electrons to unstable molecules and breaks the chain of free radical damage to cells and tissues.[2] Vitamin C is also involved in the synthesis of collagen, carnitine and neurotransmitters.[2-4] The vitamin is considered essential to humans, and while most mammals are able to synthesize vitamin C, humans cannot. As a result, exposure to smoke, pollution, radiation, heavy metal exposure and high-stress lifestyles all increase the body’s requirement for vitamin C.

Deficiency†
Severe vitamin C deficiency has been known for many centuries as scurvy, a condition characterized by subcutaneous bleeding, poor wound closure, bruising easily, hair and tooth loss, and joint pain or swelling.[2] While scurvy is rare in the majority of today’s population, current lifestyle factors raise the requirement for vitamin C. Adequate intake and retention is necessary to maintain healthy vitamin C status in the body.

Cardiovascular Health†
Research has shown vitamin C to have a strong relationship with cardiovascular health. In 2004, a pooled analysis of nine prospective cohort studies found that supplemental vitamin C intake (>400 mg/day for a mean of 10 years) supported cardiovascular health.[5] A meta-analysis of 13 randomized controlled trials (RCTs) assessed the effect of vitamin C supplementation on blood fats[6] among 549 subjects, aged 48-82 years of age. Subjects received vitamin C supplements or placebo at doses ranging from 500 to 2,000 mg/day for 4 to 24 weeks. Overall, vitamin C supplementation had a significant impact on maintaining healthy blood fats. In addition, cross- sectional studies have indicated that plasma vitamin C concentration helps maintain healthy blood pressure levels in both men and women.[7-9]
Immune Function &

Antioxidant Support†
Vitamin C supplementation has been studied for more than six decades for its role in supporting the body during immune challenges. It has been shown to stimulate both the production[10,11] and function[12,13] of white blood cells, especially neutrophils, lymphocytes and phagocytes. These immune guardians have been shown to accumulate high concentrations of vitamin C, which can protect these cell types from oxidative damage.[14,15] Through its potent antioxidant functions, vitamin C has been shown to protect white blood cells from self-inflicted oxidative damage.[16]

Connective Tissue Health†
Vitamin C’s role in collagen formation makes it vital to maintaining skin, capillary, gum, joint and skeletal health.[17]The antioxidant properties of vitamin C and its role in collagen synthesis make vitamin C vital to skin health. Keratinocytes have a high capacity for vitamin C transport, to compensate for limited blood flow to the epidermis.[18,19] Vitamin C’s role in normal tissue repair and recovery may include promoting keratinocyte differentiation,[20,21] stimulating the formation of the epidermal barrier and re-establishing the stratum corneum, the outermost layer of the epidermis.[22] Higher intakes of dietary vitamin C have been correlated with a decreased risk of dry skin.[23]

 
Directions
1 heaping teaspoon in a glass of water and drink once per day or as recommended by your health care professional.

Does Not Contain
Gluten, yeast, artificial colors and flavors.

Cautions
If you are pregnant or nursing, consult your physician before taking this product.

References
1. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. Epub 2005 Dec 21
2. From: http://lpi.oregonstate.edu/infocenter/vitamins/ vitaminC/. Accessed 1-28-14.
3. NIH Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin C. http://ods.od.nih.gov/factsheets/ VitaminC-HealthProfessional/. Accessed September 3, 2012.
4. Schlueter AK, Johnston CS. Vitamin C: overview and update. JEBCAM. 2011; 16(1) 49-57. http://chp.sagepub.com/ content/16/1/49.full.pdf+html. Accessed August 23, 2012.
5. Knekt P, Ritz J, Pereira MA, et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr. 2004;80(6):1508-1520.
6. McRae MP. Vitamin C supplementation lowers serum low- density lipoprotein cholesterol and triglycerides: a meta- analysis of 13 randomized controlled trials. J Chiropr Med. 2008;7(2):48-58.
7. Moran JP, Cohen L, Greene JM, et al. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr. 1993;57(2):213-217.
8. Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women. Nutr J. 2008;7:35.
9. Myint PK, Luben RN, Wareham NJ, Khaw KT. Association between plasma vitamin C concentrations and blood pressure in the European prospective investigation into cancer-Norfolk population-based study. Hypertension. 2011;58(3):372-379.
10. Prinz W, Bortz R, Bregin B, Hersch M. The effect of ascorbic acid supplementation on some parameters of the human immunological defense system. Int J Vitam Nutr Res. 1977;47(3):248-257.
11. Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid. In: Harris JR (ed). Subcellular Biochemistry. Vol. 25. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. New York: Plenum Press; 1996:215- 231.
12. LevyR,ShrikerO,PorathA,RiesenbergK,SchlaefferF. Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. J Infect Dis. 1996;173(6):1502-1505.
13. Anderson R, Oosthuizen R, Maritz R, Theron A, Van Rensburg AJ. The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr. 1980;33(1):71-76.
14. BergstenP,AmitaiG,KehrlJ,DhariwalKR,KleinHG,Levine
M. Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation. J Biol Chem. 1990;265(5):2584-2587.
15. EvansRM,CurrieL,CampbellA.Thedistributionofascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration. Br J Nutr. 1982;47(3):473-482.
16. Jariwalla RJ, Harakeh S. Mechanisms underlying the action of vitamin C in viral and immunodeficiency disease. In: Packer L, Fuchs J, eds. Vitamin C in Health and Disease. New York: Marcel Dekker, Inc.; 1997:309-322.
17. MacKayD,MillerAL.Nutritionalsupportforwoundhealing. Altern Med Rev. 2003 Nov;8(4):359-77. [PMID: 14653765]
18. SteilingH,LongetK,MoodycliffeA,etal.Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress. Free Radic Biol Med 2007;43:752-762.
19. Kang JS, Kim HN, Jung da J, et al. Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. J Invest Dermatol 2007;127:698-706.
20. DuarteTL,CookeMS,JonesGD.Geneexpressionprofiling reveals new protective roles for vitamin C in human skin cells. Free Radic Biol Med 2009;46:78-87.
21. Savini I, Catani MV, Rossi A, Duranti G, Melino G, Avigliano L. Characterization of keratinocyte differentiation induced by ascorbic acid: protein kinase C involvement and vitamin C homeostasis. J Invest Dermatol 2002;118:372-379.
22. Ponec M, Weerheim A, Kempenaar J, et al. The formation
of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 1997;109:348-355.
23. Cosgrove MC, Franco OH, Granger SP, Murray PG, Mayes AE. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr 2007;86:1225- 1231.

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